VAV1 GST Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	VAV1
Accession	P15498-1
Concentration	1mg/ml by Nanodrop
Amino Acid Sequence	Lys782-Cys845, with GST tag at N-terminal
Expression System	E.coli
Molecular Weight	33-43kDa (Reducing)
Purity	＞90% by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	GST Tag
Physical Appearance	Liquid
Storage Buffer	50 mM Tris, 150 mM NaCl, 1 mM DTT, 10% glycerol, pH7.5
Stability & Storage	·Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.
Reference	1. Chrencik J E, Brooun A, Zhang H, et al. Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1[J]. Journal of molecular biology, 2008, 380(5): 828-843.

Background

Vav1 Guanine Nucleotide Exchange Factor (VAV1) is a member of the VAV gene family and is exclusively expressed in the hematopoietic system. It functions as a GDP/GTP nucleotide exchange factor (GEF), activating pathways that lead to actin cytoskeletal rearrangements and transcriptional alterations. VAV1 contains several characteristic structural motifs that are crucial for its role as a versatile signal transducer.
VAV1 is essential for hematopoiesis, playing a key role in the development and activation of T cells and B cells. It has also been identified as a specific binding partner for Nef proteins from HIV-1.
Expression of VAV1 is restricted to cells of hematopoietic origin, including those of the erythroid, lymphoid, and myeloid lineages. Diseases associated with VAV1 include cherubism and HIV-1 infection.