TPO (174aa) Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	Thrombopoietin; C-mpl ligand (ML); Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor (MGDF); Myeloproliferative leukemia virus oncogene ligand;
Accession	P40226
Amino Acid Sequence	Ser22-Phe195, with C-terminal His Tag
Expression System	HEK293
Molecular Weight	26-29 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Reference	Autoimmunity. 2012 Sep;45(6):476-84. J Immunol. 2001 Jan 15;166(2):1327-33.

Background

Thrombopoietin (TPO) is a glycoprotein hormone that plays a crucial role in the regulation of platelet production by stimulating the proliferation and differentiation of megakaryocytes. The 174 amino acid (aa) form of TPO is a key isoform that has been extensively studied for its biological activities. In mice, TPO is essential for maintaining normal platelet counts and has been used as a model to understand its functions in hematopoiesis and thrombopoiesis.
TPO (174aa) is a target for the development of therapeutic agents aimed at treating thrombocytopenia and other platelet disorders. Recombinant TPO analogs and TPO receptor agonists are being developed and tested for their efficacy in increasing platelet counts. Also, TPO levels can be used as a biomarker for certain hematological conditions. Assays and kits for measuring TPO in biological samples are being developed for diagnostic purposes.