CD40 Fc&His Tag Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	Bp50，CD40 Antigens，CD40，B Cell Surface Antigen CD40，B-Cell Surface Antigen CD40，CDW40，CD40L Receptor，CD40 Molecule，Tumor Necrosis Factor Receptor Superfamily， Member 5，CD40 Molecule， TNF Receptor Superfamily Member 5，TNFRSF5，Tumor Necrosis Factor Receptor Superfamily Member 5，P50，CD40 Antigen，B Cell-Associated Molecule
Accession	P25942
Amino Acid Sequence	Glu21-Arg193 with Fc&His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	50-60kDa (Reducing)
Purity	> 95 % as determined by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, O'Rourke AM, Tynan O, Barker BE, Gallagher P, Mullan R, Hurson C, Moran B, Monaghan MG, Pitzalis C, Fletcher JM, Nagpal S, Veale DJ, Fearon U. Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset. Sci Adv. 2024 Sep 27;10(39):eadj1252.

Background

CD40, a member of the TNF receptor superfamily, is a glycoprotein crucial for immune responses. It's key for T cell-dependent processes like immunoglobulin class switching, memory B cell development, and germinal center formation. Expressed on B cells, dendritic cells, macrophages, and some tumor cells, CD40 interacts with CD40L to initiate signaling pathways. This interaction is vital for humoral immunity. CD40 defects can lead to hyper-IgM immunodeficiency type 3 (HIGM3), causing issues in B cell isotype switching and antibody responses. CD40's extracellular domain has cysteine-rich repeats, typical of TNF receptors. Early studies emphasized its role in humoral immunity.