Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	ANGPTL3, ANGPT5, ANG-5, Angiopoietin-5, FHBL2
Accession	Q9Y5C1-1
Amino Acid Sequence	Ser17-Glu460 with His Tag at the C-terminus
Expression System	HEK293
Molecular Weight	60-75 kDa (Reducing)
Purity	> 95 % as determined by SDS-PAGE & RP-HPLC; > 90 % as determined by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4,5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Arch Esp Urol. 2025 Jan;78(1):84-92. World J Gastrointest Oncol. 2025 Feb 15;17(2):97858.

Background

ANGPTL3, also known as angiopoietin-related protein 3 or angiopoietin-5 (ANGPT5), is a secreted factor in the angiopoietin-like family. Predominantly expressed in the liver, it features a signal peptide, an N-terminal coiled-coil domain, and a C-terminal fibrinogen-like domain. The fibrinogen-like domain binds alpha-5/beta-3 integrins, promoting endothelial cell adhesion and migration, and may regulate angiogenesis. ANGPTL3 also inhibits lipoprotein lipase and endothelial lipase, increasing plasma triglycerides and HDL cholesterol in rodents. By blocking endothelial lipase, it raises HDL-phospholipid levels, enhancing cholesterol efflux.