LIF Protein, Human (GMP),specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	Leukemia inhibitory factor; LIF; Differentiation-stimulating factor (D factor); Melanoma-derived LPL inhibitor (MLPLI); Emfilermin;
Accession	P15018
Amino Acid Sequence	Ser23-Phe202
Expression System	E.coli
Mycoplasma	阴性
Sterility	符合
phValue	7.8~8.2
ProteinContent	90%~120%
SdsPageMolecularWeight	20±2kD（还原）
SdsPagePurity	≥97%（非还原）
RpHplcPurity	≥95%
SecHplcPurity	≥97%
CellActivity	< 0.3ng/ml
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 200mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Development. 2005 Mar;132(5):885-96. Nat Med. 2019 May;25(5):838-849. Cell. 2015 May 7;161(4):933-45.

Background

Leukemia Inhibitory Factor (LIF) is a member of the IL-6 family of cytokines. It is a multifunctional glycoprotein with a molecular weight ranging from 28 to 45 kDa, depending on the expression system and post-translational modifications. LIF is composed of a signal peptide, an extracellular domain, and an intracellular domain, which collectively endow it with diverse biological functions. LIF is expressed in various tissues, including the liver, lungs, heart, nervous system, and immune cells, highlighting its widespread distribution and significance.
LIF is a critical cytokine widely used in biomedical research, particularly in stem cell biology and regenerative medicine. It also plays a crucial role in maintaining the pluripotency and inducing the differentiation of stem cells, the treatment of neurodegenerative diseases, the modulation of inflammatory responses.