IL-21R Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	CD360, NILR
Accession	Q9HBE5-1
Amino Acid Sequence	Cys20-Pro236 with hIgG1 Fc at the C-terminus
Expression System	HEK293
Molecular Weight	65-75kDa (Reducing)
Purity	＞95% by SDS-PAGE & ＞90% by SEC-HPLC
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS PH7.4 , 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Ren Y, Xue M, Hui X, Liu X, Farooq MA, Chen Y, Ji Y, Duan Y, Ajmal I, Yao J, Jiang W. Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer. Pharmacol Res. 2025 Feb;212:107637.

Background

Human interleukin-21 receptor (IL21R), also known as CD360 or NILR, is a type I cytokine receptor belonging to the type 4 subfamily. It contains two fibronectin type-III domains and is selectively expressed in lymphoid tissues, with the highest expression in the thymus and spleen. IL21R is crucial for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells, as it transduces the growth-promoting signals of interleukin-21 (IL-21).