IFNAR1 Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1
Accession	P17181-1
Amino Acid Sequence	Lys28-Lys436, with Human IgG1 Fc at the C-terminal
Expression System	HEK293
Molecular Weight	95-125kDa (Reducing)
Purity	＞95% by SDS-PAGE & ＞85% by SEC-HPLC
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Jacob RA, Zhang A, Ajoge HO, D'Agostino MR, Nirmalarajah K, Shigayeva A, Demian WL, Baker SJC, Derakhshani H, Rossi L, Nasir JA, Panousis EM, Draia AN, Vermeiren C, Gilchrist J, Smieja N, Bulir D, Smieja M, Surette MG, McArthur AG, McGeer AJ, Mubareka S, Banerjee A, Miller MS, Mossman K. Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerg Infect Dis. 2023 Jul;29(7):1386-1396.

Background

Interferon alpha/beta receptor 1 (IFNAR1), also known as Cytokine receptor class II member 1 (CRF2-1) or Type I interferon receptor 1, is a member of the type II cytokine receptor family. IFNAR1 contains four fibronectin type-III domains and forms the type I interferon receptor when associated with IFNAR2. As a receptor for interferons alpha and beta, IFNAR1 can transduce IFNβ signals independently of IFNAR2, although this does not activate the Jak-STAT pathway.