TACI/CD267/TNFRSF13B His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	CVID; CVID2; FLJ39942; MGC133214; ACIMGC39952; TNFRSF13B
Accession	O14836-1
Amino Acid Sequence	Ser2-Thr166 with His Tag at the C-terminus
Expression System	HEK293
Molecular Weight	19-22kDa (Reducing)
Purity	＞95% by SDS-PAGE & RP-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4,5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	von Bulow, G.U. et al. (1997) Science, 278:138. Marsters, S.A. et al. (2000) Curr. Biol. 10:785.

Background

TACI (Transmembrane activator and CAML interactor) is a type III transmembrane protein and a member of the TNF receptor superfamily. It consists of an extracellular domain containing two cysteine-rich regions, a transmembrane domain, and an intracellular domain. TACI shares high homology with BCMA and binds to APRIL and BAFF, key ligands involved in immune regulation. Expressed on B cells and activated T cells, TACI plays a crucial role in B cell development and function. Its interactions with APRIL and BAFF suggest involvement in immune signaling pathways, making it a potential target for immunotherapy.