β-defensin-3 (mBD-3) is a member of the defensin family of antimicrobial peptides, which play crucial roles in the innate immune system. These peptides are characterized by their ability to directly kill or inhibit the growth of a wide range of pathogens, including bacteria, fungi, and viruses.
In mice, the ortholog of human β-defensin-3 is known as mBD-14. It has been identified and characterized for its antimicrobial properties and immune-modulatory functions.
Similar to its human counterpart, mBD-14 exhibits potent antimicrobial activity against various pathogens and can induce chemotaxis in immune cells, such as macrophages and dendritic cells. This antimicrobial peptide is expressed in various tissues, including the gastrointestinal tract and skin, where it contributes to the maintenance of mucosal and cutaneous barriers.