IL-18Rβ/IL-1R7 Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b antigen; CD218b; CDw218b; IL-1 R7; IL-18 R beta; IL-18 receptor accessory protein; IL-18 receptor beta; IL18R beta; IL-18RAcP; IL18RAP; IL18RB; IL-18Rb; IL-18Rbeta; IL-18R-beta; IL-1R accessory protein-like; IL1R7; IL-1R7; IL-1R-7; IL-1RAcPL; interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; MGC120589; MGC120590
Accession	O95256
Amino Acid Sequence	Phe20-Arg356 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	72-95kDa (Reducing)
Purity	>95% by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4,5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.

Background

Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex consists of two subunits: IL-18Rα (also known as IL-1R5 or IL-1Rrp) and IL-18Rβ (also known as IL-1R7 or AcPL). Both subunits belong to the IL-1 receptor superfamily. IL-18R is widely expressed in various tissues, including the spleen, thymus, leukocytes, liver, lung, heart, small and large intestines, prostate, and placenta.
The IL-18 receptor complex is responsible for binding the pro-inflammatory cytokine IL-18, but not IL-1α or IL-1β. It is involved in IL-18-mediated IFNγ synthesis from T-helper 1 (Th1) cells and contributes to IL-18-induced cytokine production, either independently of SLC12A3 or as a complex with SLC12A3.