Claudin-6 membrane Protein with Flag&His Tag in Detergent, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2
Accession	P56747
Concentration	0.11 mg/ml by Nanodrop
Amino Acid Sequence	Wild type full length with Flag tag at N-Terminal，and His tag at C-Terminal
Expression System	HEK293
Molecular Weight	25.6 kDa
Purity	＞85% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tags & Cleavage sites	N/A
Tag	His Tag, Flag Tag
Physical Appearance	Liquid
Storage Buffer	50 mM Tris, pH 7.5, 150 mM NaCl, 0.05% DDM
Stability & Storage	·6 months from date of receipt, -60 to -80 °C as supplied. ·about 3 days in 2 to 8 °C. ·Please avoid repeated freeze-thaw cycles.
Reference	1. Du H, Yang X, Fan J and Du X: Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review). Mol Med Rep 24: 677, 2021.

Background

Tight junctions (TJs) are essential components of cell connectivity, maintaining cell polarity, permeability, and adhesion, and participating in the regulation of cell proliferation and differentiation. The claudin (CLDN) family is integral to TJs, with Claudin 6 (CLDN6) being a key member. CLDN6 is a transmembrane protein found in tight junctions, featuring two extracellular loops and intracellular N- and C-terminal tails. CLDN6 modulates ion- and charge-specific permeability in the paracellular pathway of most epithelial tissues.CLDN6 is widely expressed in various tumors, including liver, ovarian, endometrial, and esophageal cancers, as well as atypical teratoid/rhabdoid tumors. Given its expression profile, CLDN6 has potential as a carcinoembryonic antigen and a therapeutic target.