Product Specification| Species | Mouse | | Synonyms | High mobility group protein 1 (HMG-1); Hmgb1; Hmg-1; Hmg1; HMG3, SBP-1 | | Accession | P63158 | | Amino Acid Sequence | Met1-Glu215 with His tag at the C-Terminus | | Expression System | HEK293 | | Molecular Weight | 30-35kDa (Reducing) | | Purity | ＞95% by SDS-PAGE & ＞90% by SEC-HPLC | | Conjugation | Unconjugated | | Tag | His Tag | | Physical Appearance | Lyophilized Powder | | Storage Buffer | PBS, PH7.4, 5% trehalose | | Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. | | Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles. | | Reference | 1.Ulloa L, et al. (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201.
2.Pisetsky DS, et al. (2008) High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 10 (3): 209.
3.Volz HC, et al. (2010) The role of HMGB1/RAGE in inflammatory cardiomyopathy. Semin Thromb Hemost. 36(2): 185-94.
4.Sims GP, et al. (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28: 367-88.
5.Andersson U, et al. (2010) The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 1799 (1-2): 141-8. |
BackgroundHigh-mobility group protein B1 (HMGB1), also referred to as high-mobility group protein 1 (HMG-1) or amphoterin, is a member of the HMGB family, which includes HMGB1, HMGB2, and HMGB3. HMGB1 is a non-histone architectural chromosomal protein found in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. It plays a role in the mechanisms of inflammation and damage by binding to TLR4, thereby mediating HMGB1-dependent activation of macrophage cytokine release. This places HMGB1 at the crossroads of sterile and infectious inflammatory responses. Studies have explored HMGB1 as an adjuvant for DNA vaccines and as a potential target for cancer therapy. bio-equip.cn AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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