IGFBP-2, or insulin-like growth factor binding protein 2, is a member of the high-affinity binding protein family (IGFBP1-6) and plays a significant role in the regulation of insulin-like growth factors (IGFs) in the central nervous system. This protein is part of a family of six similar proteins that bind to IGF-I and IGF-II, influencing their bioavailability and activity in metabolic signaling. IGFBP-2 can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with various ligands. High expression levels of IGFBP-2 are associated with the growth of several types of tumors and may predict patient recovery chances.
In the biotechnology and pharmaceutical industries, IGFBP-2 is of significant interest due to its implications in various diseases and conditions. The protein's role in tumor growth makes it a potential biomarker and therapeutic target for cancer research. Elevated levels of IGFBP-2 during the progression of many human cancers suggest its importance in oncology.
Additionally, IGFBP-2's involvement in metabolic signaling pathways positions it as a key player in the study and treatment of obesity, diabetes, and other metabolic diseases.