Endothelin B Receptor His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
Accession	NP_000106.1
Amino Acid Sequence	Glu27-Lys101 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	15-28kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Maguire, J. J. & Davenport, A. P. Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. Br. J. Pharmacol. 171, 5555–5572 (2014) Davenport, A. P. et al. Endothelin. Pharmacol. Rev. 68, 357–418 (2016).

Background

Endothelin receptors, specifically ETA and ETB, are class A G protein-coupled receptors (GPCRs) that are activated by the vasoactive peptide endothelins and play a role in blood pressure regulation. Selective signaling through the ETB receptor induces vasorelaxation, making selective ETB agonists potential candidates for improved anti-tumor drug delivery and neuroprotection.