Serpin G1/C1 Inhibitor His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	SERPING1, C1IN, C1-INH, C1IN, HAE1, HAE2
Accession	P05155-1
Amino Acid Sequence	Asn23-Ala500 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	85-100kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Mahajan SD, Aalinkeel R, Reynolds JL, Machhar JS, Ghebrehiwet B, Schwartz SA. Omics analysis reveals galectin-3 to be a potential key regulator of allergic inflammation in hereditary angioedema. J Allergy Clin Immunol Glob. 2024 Oct 18;4(1):100353. Akeret K, Thomson BR, Ghosh S, Nolte M, Fischer U, Humar R, Regli L, Schaer DJ, Hugelshofer M, Buzzi RM. C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury. Fluids Barriers CNS. 2024 Nov 15;21(1):91.

Background

Serpin G1, also known as C1-inhibitor (C1-INH), is a crucial regulator of the complement, coagulation, fibrinolytic, and contact systems. The levels of protease/C1-INH complexes in the blood correlate with the in vivo activation of these four cascade-like plasma enzyme systems. C1-INH inhibits the activated forms of C1r and C1s, which are part of the first complement component, thereby regulating complement activation. Synthesized in the liver, deficiencies in C1-INH are associated with hereditary angioneurotic edema (HANE).