SIRP alphaV2/CD172a His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	SHPS1, SIRPA, CD172A, BIT, MFR, MYD1, P84, PTPNS1
Accession	ATD50864.1
Amino Acid Sequence	Glu31-Arg369 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	47-60kDa (Reducing)
Purity	＞95% by SDS-PAGE
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Tanaka Y, Hu Q, Kawazoe T, Tajiri H, Nakanishi R, Zaitsu Y, Nakashima Y, Ota M, Oki E, Oda Y, Yoshizumi T. The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer. Int J Clin Oncol. 2024 Nov 26. Shao C, Tang B, Chu JCH, Lau KM, Wong WT, Che CM, Tai WCS, Wong WT, Wong CTT. Macrophage-engaging peptidic bispecific antibodies (pBsAbs) for immunotherapy via a facile bioconjugation strategy. Chem Sci. 2024 Apr 30;15(29):11272-11278.

Background

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1), also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha), or p84, is a member of the SIRP family and belongs to the immunoglobulin superfamily. SIRP alpha is ubiquitously expressed, with particularly high levels in the brain. SIRPA/CD172a is an immunoglobulin-like cell surface receptor for CD47 and functions as a docking protein, facilitating the translocation of PTPN6, PTPN11, and other binding partners from the cytosol to the plasma membrane. SIRPA/SHPS-1 supports the adhesion of cerebellar neurons, neurite outgrowth, and glial cell attachment, and may play a key role in intracellular signaling during synaptogenesis and synaptic function.