LRRC15/LIB Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Leucine-rich repeat-containing protein 15, LRRC15, LIB, hLib
Accession	Q8TF66-1
Amino Acid Sequence	Tyr22-Gly538 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	95-105kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nagy Á, Ulmert D, Zedan W, Storey CM, Park J, Geres S, Lückerath K, Sjöström K, Westin H, Peekhaus N, Thorek DL, Karlström AE, Altai M. Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics. Eur J Med Chem. 2024 Sep 30;280: 116927.

Background

LRRC15, also known as LIB and hLib, is a leucine-rich repeat-containing protein that is highly expressed in various solid tumors. It is found on stromal fibroblasts in many solid tumors, including those of the breast, head and neck, lung, and pancreas, as well as directly on a subset of cancer cells of mesenchymal origin, such as sarcoma, melanoma, and glioblastoma. LRRC15 expression can be induced by TGFβ in activated fibroblasts (positive for α-smooth muscle actin, αSMA) and in mesenchymal stem cells. These collective findings suggest that LRRC15 serves as a novel cancer-associated fibroblast (CAF) and mesenchymal marker, making it a potential therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or those of mesenchymal origin.