Endothelin B Receptor mFc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Endothelin receptor type B; EDNRB; ET-B; ET-BR; Endothelin receptor non-selective type; ETRB
Accession	NP_000106.1
Amino Acid Sequence	Glu27-Lys101 with Mouse IgG2a Fc at C-Terminus
Expression System	HEK293
Molecular Weight	40-55kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Mouse IgG2a Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Marazziti, D. et al. (1997) Genomics, 45:68. 2.Donohue, P.J. et al. (1998) Brain Res Mol Brain Res. 54:152. 3.Omura, T. et al. (2006) J Neurochem. 99:1456. 4.Meyer, R.C. et al. (2013) Proc. Natl. Acad. Sci. U. S. A. 110: 9529

Background

GPR37 (G-protein coupled receptor 37), also known as ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor), is a 587 amino acid (aa), 7-transmembrane receptor for the neuroprotective and glioprotective factor prosaposin. It is predominantly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus. GPR37 is a substrate of the E3 ubiquitin ligase, parkin, which is upregulated during endoplasmic reticulum stress. In a juvenile form of Parkinson's disease, the accumulation of GPR37 contributes to stress-induced neuronal cell death. The extracellular domains (aa 27-265) of human and mouse GPR37 share 68% amino acid identity.