Product Specification| Species | Human | | Synonyms | Amyloid beta precursor like protein 2, APLP2, APPH, CDEBP, APPL2 | | Accession | Q06481-1 | | Amino Acid Sequence | Gly32-Ser692 with His Tag at C-Terminus | | Expression System | HEK293 | | Molecular Weight | 80-100kDa (Reducing) | | Purity | ＞95% by SDS-PAGE & SEC-HPLC | | Endotoxin | <0.1EU/μg | | Conjugation | Unconjugated | | Tag | His Tag | | Physical Appearance | Lyophilized Powder | | Storage Buffer | PBS, PH7.4, 5% trehalose | | Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. | | Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles. | | Reference | 1.Wang X, et al. (2018) Aplp2 modulates jnk-dependent cell migration in drosophila. Biomed Res Int 2018 7469714.
2.Han K, et al. (2017) Amyloid-precursor like proteins aplp1 and aplp2 are dispensable for normal development of the neonatal respiratory network. Front Mol Neurosci 10 189. |
BackgroundYWK-II protein/APLP2 is a member of an evolutionarily conserved APP family that includes amyloid precursor protein (APP) and amyloid precursor-like protein-1 (APLP1). YWK-II/APLP2 functions as a novel G(0)-protein-coupled receptor for Müllerian inhibiting substance (MIS) in cell survival. Human leukocyte antigen-B-associated transcript 3 (Bat3), an important regulator involved in apoptosis, can interact with YWK-II/APLP2 and enhance its stability by reducing its ubiquitylation and degradation by the ubiquitin-proteasome system. May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. bio-equip.cn AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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