GDF-5/BMP-14 Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14 (BMP-14);
Accession	P43027
Amino Acid Sequence	Ala376-Arg495
Expression System	E.coli
Molecular Weight	15 kDa (Reducing)
Purity	>95% by SDS-PAGE.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	50mM HAc, pH2.9
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nature. 1994 Apr 14;368(6472):639-43.

Background

Growth differentiation factor 5 (GDF-5), also known as bone morphogenetic protein 14 (BMP-14), is a member of the transforming growth factor beta (TGF-β) superfamily. It plays a crucial role in skeletal development and joint formation, as well as in the regulation of cell growth and differentiation. In mice, GDF-5/BMP-14 is essential for the proper development of bones, cartilage, and joints, and mutations in the GDF-5 gene have been associated with skeletal abnormalities and joint disorders. GDF-5/BMP-14 exerts its biological activities by binding to specific cell surface receptors and activating downstream signaling pathways that regulate gene expression and cellular functions involved in skeletal development and maintenance.