TPO(174aa) Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Thrombopoietin; C-mpl ligand (ML); Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor (MGDF); Myeloproliferative leukemia virus oncogene ligand;
Accession	P40225
Amino Acid Sequence	Ser22-Leu195, with C-terminal His Tag.
Expression System	HEK293
Molecular Weight	25-33 kDa (Reducing)
Purity	>95% by SDS-PAGE, >90% by HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	N Engl J Med. 1998 Sep 10;339(11):746-54.

Background

Thrombopoietin (TPO) is a glycoprotein hormone that plays a crucial role in the regulation of platelet production and megakaryocyte differentiation. The human TPO protein consisting of 174 amino acids is primarily produced in the liver and kidneys. TPO acts by binding to its receptor, the c-Mpl receptor, which is expressed on the surface of hematopoietic stem cells and megakaryocytic progenitor cells. Upon binding, TPO activates signaling pathways that promote the proliferation and differentiation of megakaryocytes, leading to increased platelet production. TPO is essential for maintaining normal platelet levels in the blood and is a key regulator of thrombopoiesis.