IL-12/IL-23 p40 Monomer Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Species	Human
Synonyms	Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40); IL-12 subunit p40; NK cell stimulatory factor chain 2 (NKSF2);
Accession	P29460
Amino Acid Sequence	Ile23-Ser328
Expression System	CHO
Molecular Weight	40 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nat Med. 2015 Jul;21(7):719-29. Epub 2015 Jun 29.

Background

The IL-12/IL-23 p40 monomer is a subunit shared between the interleukin-12 (IL-12) and interleukin-23 (IL-23) cytokines. It is a critical component of both the IL-12 and IL-23 heterodimers, which are proinflammatory cytokines that play essential roles in regulating immune responses. The IL-12/IL-23 p40 monomer is involved in the formation of the biologically active IL-12 and IL-23 heterodimers, which bind to their respective receptors and activate signaling pathways that modulate immune cell function. Notably, the p40 subunit itself has been shown to exhibit biological activity independent of its role in forming the heterodimers, including the ability to act as an antagonist for IL-12 and IL-23 signaling by competing for receptor binding.