Flt-3/Flk-2 Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Species	Human
Synonyms	Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2 (FLK-2); Fms-like tyrosine kinase 3 (FLT-3); Stem cell tyrosine kinase 1 (STK-1);
Accession	P36888
Amino Acid Sequence	Asn27-Asn541, with C-terminal hIgG1 Fc.
Expression System	HEK293
Molecular Weight	100-120 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Immunity. 2002 Oct;17(4):463-72.

Background

Fms-like tyrosine kinase 3 (Flt-3), also known as fetal liver kinase 2 (Flk-2), is a receptor tyrosine kinase that plays a critical role in hematopoiesis and immune cell development. Flt-3 is primarily expressed on hematopoietic stem cells and early progenitor cells, where it regulates cell proliferation, differentiation, and survival. Activation of Flt-3 by its ligand, Flt-3 ligand (Flt-3L), leads to the activation of downstream signaling pathways involved in hematopoietic cell growth and differentiation. Flt-3 is essential for the development of various immune cell lineages, including dendritic cells, natural killer cells, and B cells.