ALCAM/CD166 His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	CD166 antigen，Activated leukocyte cell adhesion molecule，CD166，ALCAM，MEMD，Activated Leucocyte Cell Adhesion Molecule，Activated-Leukocyte Cell Adhesion Molecule
Accession	Q13740-1
Amino Acid Sequence	Trp28-Ala526 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	70-90kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Swart GW. (2002) Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 81(6): 313-21.

Background

Activated Leukocyte Cell Adhesion Molecule (ALCAM), also known as Cluster of Differentiation 166 (CD166), is a type I transmembrane cell adhesion molecule that belongs to the immunoglobulin (Ig) superfamily. It serves as a ligand for CD6 and is expressed on T lymphocytes. The interaction between ALCAM and CD6 is crucial for T cell development, regulation, and for the binding of T- and B-cells to activated leukocytes.
ALCAM is expressed in a variety of tissues but is typically restricted to cell subsets involved in dynamic growth and/or migration. This includes processes such as neural development, branching organ development, hematopoiesis, immune response, and tumor progression. High expression levels of ALCAM on melanoma cell lines seem to promote metastasis, whereas in breast cancer, it has been associated with anti-metastatic activity.
ALCAM may also influence the expression or adhesion of the neuronal adhesion molecule NCAM-L1, as observed in both the developing retina and invasive melanoma.