R-Spondin1/RSPO1 Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	R-spondin-1; Roof plate-specific spondin-1 (hRspo1);
Accession	Q2MKA7
Amino Acid Sequence	Ser21-Ala263
Expression System	CHO
Molecular Weight	27 kDa (Reducing)
Purity	>95% by SDS-PAGE.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nature. 2011 Jul 4;476(7360):293-7.

Background

R-spondin 1 (RSPO1) is a secreted protein that belongs to the R-spondin family, which consists of four structurally related proteins (RSPO1-4) that act as ligands for the Wnt signaling pathway. RSPO1 plays a crucial role in regulating Wnt/β-catenin signaling by binding to the LGR4-6 receptors and enhancing the activity of Wnt ligands. This interaction leads to the stabilization of β-catenin and the activation of Wnt target genes involved in cell proliferation, differentiation, and stem cell maintenance. RSPO1 has been implicated in various developmental processes, including embryogenesis, tissue regeneration, and stem cell self-renewal. Dysregulation of RSPO1 signaling has been associated with several diseases, such as cancer and developmental disorders.