Biotinylated VSIG4 Fc&Avi Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, Z39IG, CRIg
Accession	Q9Y279-1
Amino Acid Sequence	Arg20-Pro283 with Human IgG1 Fc & Avi Tag at the C-Terminus
Expression System	HEK293
Molecular Weight	70-75kDa (Reducing)
Purity	>95% by SDS-PAGE & RP-HPLC
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	Human Fc Tag, Avi Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Pan W, Huang W, Zheng J, Meng Z, Pan X. Construction of a prognosis model of head and neck squamous cell carcinoma pyroptosis and an analysis of immuno-phenotyping based on bioinformatics. Transl Cancer Res. 2024 Jan 31;13(1):299-316. Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H. VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production. Int J Biol Macromol. 2024 Mar;260(Pt 2):129357.

Background

VSIG4 (V-set and immunoglobulin domain containing 4), also known as CRIg and Z39IG, is a type I transmembrane protein belonging to the B7 family within the immunoglobulin (Ig) superfamily. It features two Ig-like domains. VSIG4 is highly expressed in various fetal tissues, with the highest levels observed in the lung and placenta of adult tissues.
VSIG4 serves as a negative regulator of T cell activation and is believed to play a role in maintaining peripheral T cell tolerance. Additionally, it has been identified as a potent suppressor of established inflammation. The protein acts as a phagocytic receptor and exerts a strong inhibitory effect on T-cell proliferation and IL-2 production.