Flt-3/Flk-2 Protein, Mouse,specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase 2 (FLK-2); Fms-like tyrosine kinase 3 (FLT-3); Tyrosine-protein kinase receptor flk-2; CD135;
Accession	Q00342
Amino Acid Sequence	Asn28-Ser544
Expression System	HEK293
Molecular Weight	110 kDa (Reducing)
Purity	>95% by SDS-PAGE; >90% by HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nature. 2012 Apr 15;485(7397):260-3.

Background

Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that plays a critical role in hematopoiesis, particularly in the development and differentiation of hematopoietic stem cells and progenitor cells. FLT3 is expressed on the surface of hematopoietic stem cells, myeloid progenitor cells, and dendritic cells, where it regulates cell proliferation, survival, and differentiation in response to its ligand, FLT3 ligand (FL). Mutations in the FLT3 gene are commonly found in acute myeloid leukemia (AML) and are associated with poor prognosis. Inhibitors targeting FLT3 have been developed as potential therapeutic agents for AML and other hematologic malignancies.