CD31/PECAM-1 His Tag Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	PECAM1, FLJ34100, FLJ58394
Accession	P16284
Amino Acid Sequence	Gln28-Lys601 with His Tag at the C-Terminus
Expression System	HEK293
Molecular Weight	85-100kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Cao LL, Yang ZG, Qi WH, Zhang H, Bi Y, Shan Y, Cui XW, Jiang F. A preliminary study on ultrasound techniques applied to evaluate the curative effect of botulinum toxin type a in hypertrophic scars. Heliyon. 2024 Jul 19;10(15):e34723.

Background

Cluster of Differentiation 31 (CD31), also known as Platelet Endothelial Cell Adhesion Molecule (PECAM-1), is a 130-kDa transmembrane glycoprotein. It is expressed by a variety of cell types including endothelial cells, platelets, macrophages, Kupffer cells, granulocytes, T/NK cells, lymphocytes, megakaryocytes, osteoclasts, and neutrophils. CD31 is also found in certain tumors and is the sole CAM family member present on platelets.
CD31 is pivotal in the clearance of aged neutrophils and in the process of tissue regeneration. The protein facilitates cell adhesion through homotypic or heterotypic interactions, either by binding to itself or by engaging with the leukocyte integrin αvβ3. These properties enable CD31 to contribute to neutrophil recruitment during inflammatory responses and to the transendothelial migration of leukocytes. Additionally, CD31 plays a significant role in cardiovascular development.