IL-28A/IFN-λ2 Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	Interferon lambda-2; IFN-lambda-2; Interleukin-28A (IL-28A)
Accession	Q4VK74
Amino Acid Sequence	Asp20-Val193, with C-terminal 8*His
Expression System	HEK293
Molecular Weight	25-30 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nat Immunol. 2003 Jan;4(1):63-8. Epub 2002 Dec 2.

Background

Interferon lambda 2 (IFN-λ2), also known as interleukin-28A (IL-28A), is a type III interferon that belongs to the interferon lambda family. IFN-λ2 is produced in response to viral infections and plays a crucial role in the innate immune response against viruses. It exerts antiviral effects by inducing the expression of interferon-stimulated genes (ISGs) that inhibit viral replication and spread. IFN-λ2 signals through the IFN-λ receptor complex, which consists of IL-10R2 and IL-28Rα subunits, leading to the activation of downstream signaling pathways involved in antiviral defense. IFN-λ2 is considered a promising therapeutic agent for the treatment of viral infections due to its potent antiviral properties and reduced potential for side effects compared to type I interferons.