PSCA His Tag Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	Prostate stem cell antigen，UNQ206/PRO232，PRO232
Accession	P57096
Amino Acid Sequence	Leu21-Asn95, with C-terminal His
Expression System	HEK293
Molecular Weight	20-30kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, 5% trehalose, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40. 2.Yang D, Holt GE, Velders MP, Kwon ED, Kast WM. Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice. Cancer Res. 2001 Aug 1;61(15):5857-60.

Background

Prostate stem cell antigen (PSCA), a cell-membrane glycoprotein composed of 123 amino acids, is frequently expressed in prostate cancer. Mouse PSCA (mPSCA) exhibits 65% homology with human PSCA at both the nucleotide and amino acid levels. The knockdown of PSCA has been shown to induce epithelial-mesenchymal transition (EMT) and to reduce the metastatic potential of DU145 cells, indicating a significant role for PSCA in the carcinogenesis and progression of prostate cancer.