Product Specification| Synonyms | Namacizumab, Nimacimab (USAN), JNJ-2463, RYI-018 | | Concentration | ＞95% by SDS-PAGE & SEC-HPLC | | Expression System | CHO | | Molecular Weight | 25-30kDa&45-55kDa (Reducing) | | Endotoxin | <1EU/μg | | Conjugation | Unconjugated | | Physical Appearance | Lyophilized Powder | | Storage Buffer | PBS, PH7.4, 5% trehalose，5% mannitol | | Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. | | Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
| | Reference | 1. Resat Cinar,et al.The therapeutic potential of second and third generation CB1R antagonists,Pharmacology & Therapeutics,Volume 208,2020,107477,ISSN 0163-7258. |
BackgroundNimacimab is a first of its kind humanized monoclonal antibody targeting the cannabinoid 1 receptor ("CB1")that acts as a negative allosteric modulator to inhibit peripheral CB1 signaling. Inhibition of CB1 has shown anti-fibrotic, anti-inflammatory, and metabolic mechanisms of action, and has the potential to address a wide range of diseases with significant unmet medical needs, such as obesity, chronic kidney disease, and non-alcoholic steatohepatitis (NASH). bio-equip.cn AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
|
中文
