Product Specification| Species | Human | | Synonyms | MHC Class I Polypeptide-Related Sequence A; MIC-A; PERB11.1 | | Accession | Q29983-1 | | Amino Acid Sequence | Glu24-Gln308, with C-terminal Fc | | Expression System | HEK293 | | Molecular Weight | 80-95kDa (Reducing) | | Purity | >95% by SDS-PAGE & SEC-HPLC | | Endotoxin | <0.1EU/μg | | Conjugation | Unconjugated | | Tag | Human IgG1 Fc | | Physical Appearance | Lyophilized Powder | | Storage Buffer | PBS, pH7.4, 5% trehalose | | Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. | | Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
| | Reference | Journal List J Immunother Cancer v.7; 2019 |
BackgroundMICA is a protein of 383 amino acids and interacts with the NKG2D receptor and the T cell receptor (TCR) to activate NK cells, αβ CD8 T cells, and γδ T cells. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. bio-equip.cn AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
|
中文
