SDF-1α/CXCL12 Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas (IRH; hIRH), Pre-B cell growth-stimulating factor (PBSF)
Accession	P48061
Amino Acid Sequence	Lys22-Lys89
Expression System	E.coli
Molecular Weight	10 kDa (Reducing)
Purity	＞95% by SDS-PAGE & HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 800mM NaCl, PH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Cells. 2020 Oct 13;9(10):2277. Pharmacol Ther. 2022 Mar:231:107989.

Background

Fractalkine (FKN, CX3CL1) is produced in neurons and is a unique chemokine that is initially translated as a transmembrane protein but can be proteolytically processed to generate a soluble chemokine. CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or inflammation. CX3CL1 has been shown to signal through its sole receptor CX3CR1, which is located on microglial cells within the central nervous system (CNS). Although both the membrane bound and soluble forms of CX3CL1 appear to interact with CX3CR1, they do seem to have different signaling capabilities.