VEGF R2/Flk-1/KDR His Tag Protein, Rhesus macaque,specification,price,image-Bio-Equip in China

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Product Specification

Species	Rhesus macaque
Synonyms	KDR,CD309,FLK1,VEGFR,VEGFR2
Accession	F7E313
Amino Acid Sequence	Ala20-Glu764, with C-terminal His
Expression System	HEK293
Molecular Weight	100-130kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Lian, L. et al. (2019) BMC Cancer. 19:183. 2.Hu, C. et al. (2019) Onco. Targets Ther. 12:933. 3.Gao, F. et al. (2020) Curr. Cancer Drug Targets. 20:3.

Background

Vascular endothelial Growth Factor Receptor 2 (VEGFR2), also known as FLK-1, KDR, and CD309, is a type I single-pass membrane receptor，and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). Mature VEGFR2 contains a 745 amino acid extracelluar domain with seven immunoglobulin-like repeats, 21 transmembrane domain and 571 cytoplasmic domain. Within the extracellular domain, human VEGFR2 shares 80% homology with that of mouse and rat. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.