Fractalkine/CX3CL1 Protein, Rat,specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Species	Rat
Synonyms	Fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1
Accession	Q55145
Amino Acid Sequence	Gln25-Gly100
Expression System	E.coli
Molecular Weight	9kDa (Reducing)
Purity	＞95% by SDS-PAGE&HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 200mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Cells. 2020 Oct 13;9(10):2277. Int J Mol Sci. 2020 May 25;21(10):3723. Adv Exp Med Biol. 2020:1231:1-12.

Background

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). It signals through its unique receptor, CX3CR1, that is expressed in microglia. The biological effects elicited by CX3CL1 on surrounding cells vary depending on a number of factors including its structure, the expression pattern of CX3CR1, and the cell type. Fractalkine/CX3CL1 chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma.