MIP-1β/CCL4 Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Species	Human
Synonyms	C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4
Accession	P13236
Amino Acid Sequence	Ala24-Asn92
Expression System	E.coli
Molecular Weight	15kDa (Reducing)
Purity	＞95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 300mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. T Nguyen-Hoai (2016) Cancer Gene Ther. 23(6):162-7. 2. Dabin Lee (2018) Cell Death Dis . 9(5):495.

Background

CCL4 (macrophage inflammatory protein-1β, MIP-1β) is a CC chemokine that belongs to the group of inflammatory chemokines and acts as a chemoattractant for different immune effector cells such as immature DC, TH1 T cells, NK cells and monocytes. In contrast to CCR7 that is expressed on mature DC and naive T-cell subsets, the CCL4 receptor CCR5 is expressed on immature DC and TH1-polarized T cells. CCL4 can activate chemokine receptor CCR5, which is involved in diverse immune responses. Among the diverse chemokines, CCL4 and its receptor CCR5 have been a focus of research on HIV. CCL4 is also secreted by CD8 + T cells and attracts monocytes, natural killer cells, and other immune cells.