NT-3 Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	HDNF,Nerve growth factor 2,NGF-2,Neurotrophic factor,NTF3
Accession	P20783
Amino Acid Sequence	Tyr139-Thr257 YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
Expression System	E.coli
Molecular Weight	15kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 500mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Elizabeth Hernández-Echeagaray (2020) Vitam Hor. 114:71-89. 2. F Marmigère. (2001) Neuroendocrinology 74(1):43-54.

Background

Neurotrophin-3 (NT-3) belongs to a family of growth factors called neurotrophins whose actions are centered in the nervous system. The neurotrophin family includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4/5 (NT-4/5), neurotrophin-6(NT-6) and the recently cloned neurotrophin-7 Most of biological effects of neurotrophins are mediated by high affinity tyrosine kinase (Trk) receptors, although some of them require the binding to a low affini tyreceptor (p75LNTR). NGF binds to TrkA receptors, BDNF preferentially activates TrkB receptors, while NT-3 mainly interacts with TrkC receptors, and at lower affinity with TrkB receptors. NT-3 is structurally related to other neurotrophins like brain-derived neurotrophic factor. The expression of NT-3 starts with the onset of neurogenesis and continues throughout life. A wealth of information links NT-3 to the growth, differentiation, and survival of hippocampal cells as well as sympathetic and sensory neurons.