MARCO His Tag(79-520) Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2
Accession	Q9UEW3
Amino Acid Sequence	Met79-Val520, with N-terminal His
Expression System	HEK293
Molecular Weight	60-75kDa (Reducing)
Purity	＞95% by SDS-PAGE, >95% by RP-HPLC & >90% by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Kriemler L, Rudin S, Gawinecka J, Gross F, Arnold M, Schweizer J, Westphal L, Inauen C, Pokorny T, Dittrich T, Toebak A, Arnold M, Christ-Crain M, von Eckardstein A, Rentsch K, Katan M, De Marchis GM. Discordance between LDL-C and apolipoprotein B is associated with large-artery-atherosclerosis ischemic stroke in patients ⩽70 years of age. Eur Stroke J. 2024 Jan 26:23969873231221619. 2. Furlani F, Pota G, Rossi A, Luciani G, Campodoni E, Mocerino F, D'Errico G, Pezzella A, Panseri S, Vitiello G, Sandri M. Designing bioinspired multifunctional nanoplatforms to support wound healing and skin regeneration: Mg-hydroxyapatite meets melanins. Colloids Surf B Biointerfaces. 2024 Jan 15;235:113756.

Background

MARCO (macrophage receptor with collagenous structure), also known as SCARA2, is an 80 kDa type II transmembrane glycoprotein that belongs to the class A scavenger receptor family. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. Its expression is induced on Kupffer cells and alveolar macrophages by microbial infection, chemical irritants, and Th1 polarizing factors. MARCO binds LPS, lipoteichoic acid, and other determinants on Gram positive and negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2. MARCO is required for the organization of the splenic marginal zone and the interaction of local macrophages and B cells.