IL-21 Protein, Rat,specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Species	Rat
Synonyms	Interleukin-21, IL-21
Accession	A3QPB9
Amino Acid Sequence	His18-Ser146
Expression System	E.coli
Molecular Weight	15kDa
Purity	＞95% by SDS-PAGE&RP-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 400mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.J Immunotoxicol. 2016 May;13(3):274-85. 2.Epub 2015 Oct 28. 2.Front Cell Infect Microbiol. 2019 Dec 4:9:401. 3.eCollection 2019. 3.Med Oncol. 2023 May 30;40(7):191.

Background

Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation of helper T (TH)-17 and follicular helper T (TFH) cells, activation of natural killer (NK) cells, enhancing B-cell differentiation and antibody secretion and suppression of regulatory T (Treg) cells. Actually IL-21 is a pleiotropic cytokine whose functions in protection and immunopathology during parasitic diseases have been explored in limited ways, and it has been revealed to elicit antitumor-immune responses in several tumor models.