DUSP6 His Tag Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP-3)
Accession	Q16828
Amino Acid Sequence	Met1-Thr381, with N-terminal His
Expression System	E.coli
Molecular Weight	43kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, 2mM TCEP, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Nat Commun. 2022 Nov 5;13(1):6672. Int J Mol Sci. 2023 Apr 22;24(9):7690.

Background

Dual-specific phosphatase-6 (DUSP6), also known as mitogen-activated protein kinase phosphatase-3 (MKP3), has been characterized as a negative feedback regulator of ERK1/2 signaling. It serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). DUSP6 is a cytoplasmic DUSP known to catalyze the removal of phosphate groups from threonine and tyrosine residues on Erk1/2, Which belongs to a family of 25 protein phosphatases that dephosphorylate phosphotyrosine and phosphoserine/phosphothreonine residues within the same substrate.