Endoglin/CD105 Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Endoglin,CD105,ENG,END
Accession	P17813-1
Amino Acid Sequence	Glu26-Gly586, with C-hIgG1 Fc
Expression System	HEK293
Molecular Weight	90-95kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Physical Appearance	Lyophilized Powder
Storage Buffer	1*PBS, pH7.4,5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.MINI REVIEW article Front. Med., 30 January 2019 Sec. Translational Medicine Volume 6 - 2019 \| https://doi.org/10.3389/fmed.2019.00010.

Background

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. As a TGF-beta coreceptor, CD105/Endoglin activates SMAD transcription factors, participating in the TGF-beta/BMP signaling cascade.