Login    Join free Add to favorites    中文
Home >Products> Reagents >Other Reagents> Biotinylated Angiopoietin-2/ANGPT2 (275-496) Avi&His Tag Protein, Human
Biotinylated Angiopoietin-2/ANGPT2 (275-496) Avi&His Tag Protein, Human
Biotinylated Angiopoietin-2/ANGPT2 (275-496) Avi&His Tag Protein, Human
Origin of place Singapore
Model UA010902-25μg
Supplier ANT BIO PTE.LTD.
Price 556
Hits 5
Updated 8/27/2025
  • Product Detail
  • Company Profile

Product Specification


SpeciesHuman
SynonymsANGPT2, AGPT2, ANG2
AccessionO15123-1
Amino Acid SequenceLys275-Phe496, with N-terminal Avitag and His
Expression SystemHEK293
Molecular Weight30-35kDa (Reducing)
Purity>95% by SDS-PAGE
Endotoxin<1EU/μg
Physical AppearanceLyophilized Powder
Storage BufferPBS, pH7.4.
ReconstitutionReconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Racheal G. Akwii, Md S. SajibORCID, Fatema T. Zahra, Constantinos M. Mikelis; Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology. Cells 2019, 8(5), 471; https://doi.org/10.3390/cells8050471.

Background

Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 is also critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.

bio-equip.cn
Request Infomation

* Name:
Title:
* Tel:
Fax:
* E-mail:
Postcode:
Institution/Company:
Address:
* Country:
Request infomation:
yes no
Request Quotation:
yes no
* Message:
Validated Code:
refresh
I agree to share my inquiry to the other matching suppliers.



Copyright(C) 2006-2025 Bio-Equip    E-mail:web@bio-equip.cn   沪ICP备06040519号