Fc γ RIIA/CD32a His Tag Protein, Cynomolgus,specification,price,image-Bio-Equip in China

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Product Specification

Species	Cynomolgus
Synonyms	Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2
Accession	Q8SPW4-1
Amino Acid Sequence	Gln28-Pro208, with C-terminal His
Expression System	HEK293
Molecular Weight	30-35kDa(Reducing)
Purity	＞95%, by SDS-PAGE under reducing conditions
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.

Background

IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three subtypes: RI (CD64), RII (CD32) and RIII (CD16). There are three human Fc γ RII / CD32 genes (A, B and C), two crab eating monkeys (An and B), and one Fc γ RII B in mice. Fc γ RIIA of cynomolgus monkey consists of extracellular domain, transmembrane domain and cytoplasmic domain. The extracellular domain includes two IgG domains. The Fc γ RIIA protein of crab-eating monkey has 89% homology with human Fc γ RIIA. CD32a is expressed in a variety of immune cells such as macrophages, neutrophils and platelets. When it binds to ligands, it initiates inflammatory responses, including cytolysis, phagocytosis, degranulation and production of cytokines. This response can be regulated by co-expression of inhibitory receptors such as CD32B.