FGF-21 Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	FGF-21;Fibroblast Growth Factor 21, FGF-21, FGF21
Accession	Q9NSA1-1
Amino Acid Sequence	His29-Ser209, with N-terminal His Tag
Expression System	HEK293
Molecular Weight	25-28 KDa(Reducing)
Purity	＞95%, by SDS-PAGE under reducing conditions
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.2, 5% trehalose
Reconstitution	Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.

Background

Fibroblast growth factor 21 (FGF-21) is a member of the FGF gene family. According to its structure, it is further classified as a member of the FGF19 subfamily. The subfamily includes FGF-19,-21 and-23. FGF-21 is an effective adipocyte glucose uptake activator that protects animals from diet-induced obesity when overexpressed in transgenic mice and reduces blood glucose and triglyceride levels during treatment in diabetic rodents. Some studies have shown that FGF-21 is a biomarker for the diagnosis of mitochondrial diseases. FGF-21 can cross the blood-brain barrier and regulate the phosphorylation cascade and gene expression in the whole hypothalamus. Intracerebroventricular injection of FGF21 can increase metabolic rate and insulin sensitivity in rats, but the site of action is not clear.