Her2 Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Her2, ERBB2, CD340, HER-2/neu, MLN19, NEU, NG, TKR1
Accession	P04626-1
Amino Acid Sequence	Thr23-Thr652, with C-hIgG1 Fc
Expression System	HEK293
Molecular Weight	110-120kDa
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human Fc Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Schlessinger J. (2000) Cell Signaling by Receptor Tyrosine Kinases. Cell. 103(2): 211-225. 2、Codony-Servat J et al. (1999) Cleavage of the HER2 Ectodomain Is a Pervanadate-activable Process That Is Inhibited by the Tissue Inhibitor of Metalloproteases-1 in Breast Cancer Cells. Cancer Res. 59(6): 1196-1201.

Background

The HER2/neu gene is one of the family of genes encoding transmembrane receptors for four growth factors, including the epidermal growth factor receptor (EGFR), HER2/neu, HER3, and HER4. The HER2/neu gene is localized on the long arm (q21) of chromosome 17. This gene codes for a 185 kDa receptor-type tyrosine protein kinase (p185 neu or c-erbB-2) similar to EGFR. This 1255 amino acid transmembrane glycoprotein is composed of three domains: an extracellular factor-binding domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. The intracellular domain of HER2/neu has tyrosine kinase activity, which regulates cell growth and proliferation. HER2/neu is over-expressed in 20-25% of invasive breast cancers and is associated with an aggressive tumor, early relapse, and reduced survival.