FGF-12 Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Antigen	FGF-12
Synonyms	Fibroblast growth factor homologous (FHF-1), Myocyte-activating factor, FGF12B
Accession	P61328-2
Amino Acid Sequence	Met1-Thr181
Expression System	E.coli
Molecular Weight	21kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM PB, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1463-73.

Background

Fibroblast growth factor 12 (FGF-12), also known as fibroblast growth factor homologous factors (FHF), is cytosolic proteins that is homologous to fibroblast growth factors but is not secreted. FGF12 modulates both cardiac Na+ and Ca+ channel by binding to the conserved proximal part of the C-terminal domain of voltage-gated sodium channels Nav1.5. However, a single missense mutation in FGF12-B (Q7R-FGF12) reduced binding to the NaV1.5 C-terminus, yielding a Brugada Syndrome phenotype.