FGF-8b Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Fibroblast growth factor 8b,FGF8
Accession	P55075
Amino Acid Sequence	Gln23-Arg215
Expression System	E.coli
Molecular Weight	25kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 150mM NaCl, 1mM EDTA, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.

Background

Fibroblast growth factor 8b (FGF-8b), a secreted heparin-binding protein, is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. Alternative splicing of fgf-8 gene gives rise to potentially four (a, b, e, f) different protein isoforms in human, and FGF-8b exhibits the highest transforming activity in NIH3T3 cells. FGF-8b signals through FGF receptors (FGFRs) to activate PI3K and MAPK pathways. FGF-8b is broadly associated with mitogenic and cell survival activities, and regulates gastrulation, epithelial-mesenchymal transition, and later on mesenchymal to epithelial differentiation during embryonic development. FGF-8b has also been found in peripheral blood leukocytes and healthy bone marrow samples.