FGF-21 Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	FGF-21, Fibroblast growth factor 21
Accession	Q9JJN1
Amino Acid Sequence	Ala29-Ser210
Expression System	E.coli
Molecular Weight	20kDa
Purity	>95% by SDS-PAGE & RP-HPLC
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM PB, 150mM NaCl, pH 7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Kharitonenkov A J. et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-1635. 2、Guo A. et al. (2020) Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets? Exp Gerontol. 139: 111022. 3、Gomarasca M. et al. (2020) Myokines: The endocrine coupling of skeletal muscle and bone. Adv Clin Chem. 94: 155-218.

Background

Fibroblast Growth Factor 21(FGF-21) is a member of the fibroblast growth factor (FGF) family and it is involved in the modulation of cell proliferation, growth, and differentiation as well as cell metabolism. This protein is a secreted endocrine factor that functions as a major metabolic regulator, and stimulates the uptake of glucose in adipose tissue. FGF21 binds to FGFR1c complexed with β-Klotho expressed in adipocytes to activate the canonical FGF signaling pathway (ERK1/2) and the AMPK/PGC1α pathway. Therefore, FGF-21 is being pursued as a therapeutic target for diabetes and obesity.