IL-21 Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	IL-21, rMuIL-21, Za11
Accession	Q9ES17
Amino Acid Sequence	Pro25-Ser146
Expression System	E.coli
Molecular Weight	14kDa
Purity	>95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 100mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Coquet J M. et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34. 2、Wei L. et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10. 3、Parrish-Novak J. et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4、Kuchen S. et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9): 5886-96.

Background

IL-21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. IL-21 is a T-cell–derived cytokine that works in concert with other γc cytokines. It synergizes with IL-7 and IL-15 to expand and activate CD8 T cells. IL-21 also augments the activity of NK cells. IL-21, along with IL-6, drives differentiation of Tfh. Tfh cells are found preferentially in B-cell follicles, where, under the control of the transcription factor BCL6, they regulate B-cell development, activation, and class switching. Tfh cells are also a source of IL-21. IL-21 appears to have some anticancer properties, and it has been tested in the treatment of melanoma.