LYPD8 Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	LYPD8, LY6, PLAUR domain containing 8
Accession	Q6UX82
Amino Acid Sequence	Leu20-Asn215, with C-terminal Human IgG1 Fc LSCVQCNSWEKSCVNSIASECPSHANTSCISSSASSSLETPVRLYQNMFCSAENCSEETHITAFTVHVSAEEHFHFVSQCCQGKECSNTSDALDPPLKNVSSNAECPACYESNGTSCHGKPWKCYEEEQCVFLVAELKNDIESKSLVLKGCSNVSNATCQFLSGENKTLGGVIFRKFECANVNSLTPTSAPTTSHNIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System	HEK293
Molecular Weight	60-95kDa
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human Fc Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Okumura R. et al. (2020) Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia. Mucosal Immunol. 13: 75-85.

Background

Lypd8 is a highly N-glycosylated glycosylphosphatidylinositol-anchored protein that is highly expressed on colonic IECs and constitutively shed into the intestinal lumen. Lypd8 inhibits the invasion of colonic epithelia by flagellated commensal bacteria such as Proteus mirabilis and E. coli belonging to Enterobacteriaceae family by suppressing their motility via flagella binding. However, it remains unclear whether Lypd8 has a protective function against pathogenic bacteria, including pathogenic E. coli, Salmonella, Shigella, and Citrobacter, many of which belong to the family Enterobacteriaceae.